Medical Thesis

The research groups of the Institute of Neuropathology are searching for ambitious students which would like to carry out a superior experimental doctorate. The research of molecular fundamentals of human epilepsy, molecular myopathies and brain tumors forms the scientific emphasis.

As far as our experience goes the projects offered, are particularly suitable for medics within the 1rst until 4th clinical semester with a great interest in a scientific education.

During the practical work which takes about 9 months, the study should be stopped out for one semester. To guarantee an efficient education and support you should work full-time in the lab. It is further mandatory to attend our Seminar on Clinical Neuropathology

Should you require any further information, please do not hesitate to contact us personally or through E-Mail.

Currently the following projects can be allocated:  

Molecular Epilepsy Research

"We are intersted in the molecular pathogenesis of human focal epilepsies and developmental disorders of the brain. Our focus is on localized and global epigenetic gene regulation in seizure development as well as metabolic interference with epigenetic mechanisms. We use rat primary neuronal cell-cultures as in-vitro model and human surgical brain tissue obtained from epilepsy patients for our research. The methods applied depend on the specific project, but may include immunofluorescence/-histochemistry, molecular biology, and protein biochemistry. Interested students should be willing work constantly in the lab for 6 to 9 months (full-time). Students who stay in the lab for a minimum of 7 months are encouraged to apply for a fellowship of the local IZKF."

Clinical Epilepsy Research

"We offer interesting works which deal with the molecular pathogenesis of focal epilepsy associated with hippocampal sclerosis, focal cortical dysplasia or brain tumors. We use human surgical brain tissue obtained from epilepsy patients for our research and mainly apply immunohistochemistry/-fluorescence and (digital) microscopy. Interested students should be willing work constantly in the laboratory for 6 to 9 months (full-time)."

Molecular Myopathies

"We deal with the molecular pathogenesis of protein aggregation disorders in human skeletal muscle. For this purpose, transgenic mouse models have recently been prepared, which are now to be subjected to a systematic histological, immunohistochemical and protein biochemical analysis. For this purpose, we are looking for motivated doctoral candidates who are interested in molecular genetic methods. Duration about 9 months (full-time)." 

Neuro-Oncology

"We are interested in the molecular pathogenesis of tumors of the sella region, in particular pituitary adenomas and craniopharyngeomas. We are looking for motivated doctoral candidates who are interested in molecular genetic methods. Duration about 9 months (full-time)".